← BioTransfer GEO Dataset Finder
GEO series

Region-specific roles of stress-activated protein kinase MKK7 in the developing and maturing murine brain

GSE293965 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/09 Platform GPL34290
Summary
The stress-responsive kinase MKK7 controls various brain functions. Neural stem cell-specific deletion of the Mkk7 gene caused abnormal brain development and death immediately after birth (perinatal lethality). However, the region-specific roles of MKK7 during embryonic brain development remain unclear. We have found that the mice with loss of MKK7 in the cerebrum were born at the expected Mendelian ratio but died within five weeks of birth. To investigate its molecular mechanism, we performed RNA-sequencing analysis in the brain.
Published in
Region-specific roles of stress-activated protein kinase MKK7 in the developing and maturing murine brain
Kofuji S, Qian Y, Nishina H · Scientific reports 2025 · PMID 40594443 · doi:10.1038/s41598-025-05388-0
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE293965_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1247508 and SRA study SRP576988. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.