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Isolated TEC and DC from human iPSc-derived thymic organoids (hTOs) seeded with primary early thymic progenitors (ETPs) at late phase of maturation (D28)

GSE294061 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/11/21 Platform GPL18573
Summary
We employed an ultra-sensitive bulk RNA sequencing approach to study thymic epithelial cells (TECs), sorted by FACS based on their HLA-DR expression levels, and dendritic cells (DCs), both isolated from hTOs at the late stage of differentiation (day 28). These hTOs were generated by reaggregating iPSc-derived thymic epithelial progenitors (TEPs) with primary ETPs.
Published in
Combinatory differentiation of human induced pluripotent stem cells generates functional thymic epithelium driving dendritic cell and CD4/CD8 T cell development
Provin N, d'Arco M, Le Bozec A et al. · Nature communications 2026 · PMID 41577697 · doi:10.1038/s41467-026-68675-y
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Also filed as BioProject PRJNA1247982 and SRA study SRP577247. Searching any of these in the dataset finder brings you back here.

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