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Piezo1 dictates K⁺ homeostasis through coordinated regulation of the ubiquitin ligase Kelch-like 3 in RBCs and the kidney

GSE294294 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/01/01 Platform GPL34871
Summary
The maintenance of potassium (K+) balance is a fundamental biological process involving multiple organs. However, mechanisms by which inter-organ communication regulates K+ homeostasis remain largely unexplored. By combining human genetics and mouse model generation using CRIPSR/Cas9, we demonstrate that the ubiquitin ligase Kelch-like 3 (KLHL3) orchestrates K⁺ transport across K⁺-storing erythrocytes and K⁺-excreting kidneys by interacting with the mechanosensitive Ca2+ channel Piezo1.
Published in
Piezo1 dictates K(+) homeostasis through coordinated regulation of the ubiquitin ligase Kelch-like 3 in RBCs and the kidney
Ishizawa K, Kaseda K, Fujii W et al. · Proceedings of the National Academy of Sciences of the United States of America 2026 · PMID 41533447 · doi:10.1073/pnas.2513222123
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Also filed as BioProject PRJNA1248956 and SRA study SRP577977. Searching any of these in the dataset finder brings you back here.

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