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Regulation of STK38 by autophagy governs YAP1 activity during paligenosis

GSE294328 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/03/15 Platform GPL24247
Summary
Paligenosis is a conserved process that enables mature cells to reenter the cell cycle in response to tissue injury, progressing through stages of autodegradation, gene expression changes, and proliferation. The Hippo signaling pathway, particularly YAP1, plays a key role in regulating this process, with Serine/Threonine Kinase 38 (STK38) identified as a key regulator that inhibits YAP1 in uninjured cells but is degraded via autophagy during injury. This degradation of STK38 leads to YAP1 activation, which drives cellular plasticity and proliferation. Additionally, the secretory maturation factor MIST1 helps preserve STK38 function, suggesting a broader, evolutionarily conserved role for autophagy in tissue regeneration.
Published in
Regulation of STK38 by autophagy governs YAP1 activity during paligenosis
Zeng Y, Huang YZ, Li QK et al. · Proceedings of the National Academy of Sciences of the United States of America 2026 · PMID 41911447 · doi:10.1073/pnas.2517488123
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Also filed as BioProject PRJNA1249027 and SRA study SRP578033. Searching any of these in the dataset finder brings you back here.

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