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Cold-inducible RNA-binding protein promotes lung fibroblast activation via TLR2/4-dependent IL-6 signaling: implications in pulmonary fibrosis

GSE294583 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/11 Platform GPL24247
Summary
This study investigates the role of Cold-inducible RNA-binding protein (CIRBP) in the pathogenesis of pulmonary fibrosis. Using RNA-seq, we analyzed gene expression changes in primary mouse lung fibroblasts stimulated with recombinant CIRBP or PBS control. CIRBP significantly upregulated cytokine-related gene expression, including IL-6, and promoted collagen production and fibroblast proliferation via TLR2/4 pathways.
Published in
Cold inducible RNA binding protein promotes fibroblast activation and its inhibition represents a potential therapeutic target in pulmonary fibrosis
Mochizuka Y, Hozumi H, Watanabe H et al. · Scientific reports 2026 · PMID 41667819 · doi:10.1038/s41598-026-39649-3
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Also filed as BioProject PRJNA1250537 and SRA study SRP578454. Searching any of these in the dataset finder brings you back here.

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