CDA HFD mice analysed for hepatic gene expression after treatment with semaglutide
RNA-seq (gene expression) · mouse · 97 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 97 samples: 97 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitisNature medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE294630_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1250966 and SRA study SRP578675. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 97 sample titles: 97 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8912821 16655.fastq.gz,41,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_12w,10090
- GSM8912822 16656.fastq.gz,9,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912823 16657.fastq.gz,87,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_18w,10090
- GSM8912824 16658.fastq.gz,104,GUS2021_558_NN,Liver,CDAA_Baseline_group_6_w,10090
- GSM8912825 16659.fastq.gz,101,GUS2021_558_NN,Liver,CDAA_Baseline_group_6_w,10090
- GSM8912826 16660.fastq.gz,65,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_12w,10090
- GSM8912827 16661.fastq.gz,91,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_18w,10090
- GSM8912828 16662.fastq.gz,83,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_18w,10090
- GSM8912829 16663.fastq.gz,28,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_18w,10090
- GSM8912830 16664.fastq.gz,105,GUS2021_558_NN,Liver,CDAA_Baseline_group_6_w,10090
- GSM8912831 16665.fastq.gz,50,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_12w,10090
- GSM8912832 16666.fastq.gz,10,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912833 16667.fastq.gz,7,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912834 16668.fastq.gz,57,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_12w,10090
- GSM8912835 16669.fastq.gz,42,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_12w,10090
- GSM8912836 16670.fastq.gz,40,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_12w,10090
- GSM8912837 16671.fastq.gz,6,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912838 16672.fastq.gz,47,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_12w,10090
- GSM8912839 16674.fastq.gz,20,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912840 16675.fastq.gz,80,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_18w,10090
- GSM8912841 16676.fastq.gz,58,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_12w,10090
- GSM8912842 16677.fastq.gz,39,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_12w,10090
- GSM8912843 16678.fastq.gz,3,GUS2021_558_NN,Liver,Chow_18w,10090
- GSM8912844 16679.fastq.gz,72,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_18w,10090
- GSM8912845 16680.fastq.gz,11,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912846 16681.fastq.gz,14,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912847 16682.fastq.gz,59,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_12w,10090
- GSM8912848 16683.fastq.gz,21,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_18w,10090
- GSM8912849 16684.fastq.gz,55,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_12w,10090
- GSM8912850 16686.fastq.gz,22,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_18w,10090
- GSM8912851 16687.fastq.gz,48,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_12w,10090
- GSM8912852 16688.fastq.gz,19,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912853 16689.fastq.gz,66,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_18w,10090
- GSM8912854 16690.fastq.gz,82,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_18w,10090
- GSM8912855 16691.fastq.gz,69,GUS2021_558_NN,Liver,Sema_10_nmol_per_kg_QD_6_18w,10090
- GSM8912856 16692.fastq.gz,1,GUS2021_558_NN,Liver,Chow_18w,10090
- GSM8912857 16693.fastq.gz,78,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_18w,10090
- GSM8912858 16694.fastq.gz,84,GUS2021_558_NN,Liver,CDAA_vehicle_QD_6_18w,10090
- GSM8912859 16695.fastq.gz,13,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
- GSM8912860 16696.fastq.gz,16,GUS2021_558_NN,Liver,Chow_reversal_vehicle_QD_6_12w,10090
+ 57 more — browse all 97 samples with per-sample file links →
- GSE338091 Effect of semaglutide treatment in aged mice 10 samples shares semaglutide, treatment
- GSE217560 Gene expression profile at single cell level of bone marrow and brain cells from young adult and aged mouse after chewing diet (CD) and long-term high-fat diet (HFD) feeding 8 samples shares hfd
- GSE293937 scRNA-seq of fasted or 1 hour refed mouse hypothalamus after 6 weeks of HFD 13 samples shares hfd
- GSE302874 HFD-inducued metabolic syndrome is promoted by JNK7b isoform. 69 samples shares hfd
- GSE254704 Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice 32 samples shares hfd
- GSE286167 Ceramides drive colorectal cancer metastasis through a revival stemness program [BulkRNAseq_HFD] 23 samples shares hfd
- GSE277336 HFD-inducued metabolic syndrome is promoted by JNK7b isoform 20 samples shares hfd
- GSE244342 Activated-ATF6α is an ER stress-inducing oncoprotein metabolically restricting immunosurveillance [bulk RNA-seq of TG-AAV-GFP/CRE, DEN/HFD] 16 samples shares hfd
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.