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Single cell RNA sequencing data obtained from aortic specimens of Fbn1G234D/G234D mouse model

GSE294679 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/30 Platform GPL21103
Summary
We generated a novel genetic mouse model of fatal aortic dissection by introducing a pathogenic variant of Fbn1 (Fbn1G234D/G234D), identified in a patient with familial aortic dissection, into mice using the CRISPR/Cas9 system. To investigate the cellular heterogeneity underlying the progression of aortic dissection, we performed single cell RNA sequencing on aortic tissues obtained from Fbn1G234D/G234D (AD) and wild-type mice (WT).
Published in
Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune Infiltration
Kimura K, Motoyama E, Kanki S et al. · Circulation research 2025 · PMID 40365676 · doi:10.1161/CIRCRESAHA.125.326230
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Direct links to NCBI, no account and no request form: the whole study as GSE294679_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1251079 and SRA study SRP578861. Searching any of these in the dataset finder brings you back here.

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