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Impact of TCF-1 de-repression on effector gene expression programs [RNAseq_Tcf7del22+17]

GSE294882 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/02 Platform GPL34290
Summary
The transcription factor TCF-1 is downregulated during effector differentiation of CD8+ T cells. However, how its downregulation impacts gene expression in different effector- and memory-biased populations remains unclear. Here, we generate mice in which TCF-1 fails to become downregulated in differentiated effector cells and probe the transcriptional impact of TCF-1 retention in different T cell differentiation states bybulk RNA-sequencing of KLRG1+ effector T cells.
Published in
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8(+) T cells
Murphy MK, McCullen M, Deffenbaugh JL et al. · Immunity 2025 · PMID 41043414 · doi:10.1016/j.immuni.2025.09.008
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Also filed as BioProject PRJNA1251099 and SRA study SRP578839. Searching any of these in the dataset finder brings you back here.

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