GEO series
DSS chronic colitis induces osteoporosis by changing osteal macrophages to an inflammatory phenotype.
GSE295136
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/03/15
GPL24247
Summary
Osteal macrophages are bone-resident macrophages.In this study, we investigated the functional properties of Osteal macrophages in osteoporosis caused by chronic colitis. In this study, we investigated the functional properties of Osteal macrophage in osteoporosis caused by chronic colitis.We found that Osteal macrophages are altered in an inflammatory manner and affect osteoblast and osteoclast differentiation. To understand this mechanism, we isolated and collected Osteal macrophages from mice with DSS-induced colitis and comprehensively analyzed changes in gene expression by bulk RNA analysis
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