GEO series
Id2 acts as a metabolic checkpoint underpinning Th17 cell fate decision [CUT&Tag]
GSE295289
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
11 samples
2025/07/13
GPL24247
Summary
T helper 17 (Th17) cells protect barrier tissues but also trigger autoimmunity. The precise mechanisms control these opposing processes remain unclear. We identify Id2 as a key factor for pathogenic Th17 cells. Id2 expression is markedly elevated in Myelin-reactive T cells from multiple sclerosis (MS) patients and autoimmune mice. Mice lacking Id2 in Th17 cells completely fail to develop neuroinflammation and do not generate neuron-pathogenic Th17 subset.
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