Transcriptomic Expression Profile Changes in Lung Tissue of Asthmatic Mice
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 6 × lung, sham, vs 5 × lung, OVA-chanllege,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BHLHE40 contributes to allergic asthma progression in mice through NRTN downregulation in macrophagesCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295506_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1255068 and SRA study SRP581026. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 2 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8951646 lung, sham, rep1 lung, sham,
- GSM8951647 lung, sham, rep2 lung, sham,
- GSM8951648 lung, sham, rep3 lung, sham,
- GSM8951649 lung, sham, rep4 lung, sham,
- GSM8951650 lung, sham, rep5 lung, sham,
- GSM8951651 lung, sham, rep6 lung, sham,
- GSM8951652 lung, OVA-chanllege, rep1 lung, OVA-chanllege,
- GSM8951653 lung, OVA-chanllege, rep2 lung, OVA-chanllege,
- GSM8951654 lung, OVA-chanllege, rep3 lung, OVA-chanllege,
- GSM8951655 lung, OVA-chanllege, rep4 lung, OVA-chanllege,
- GSM8951656 lung, OVA-chanllege, rep6 lung, OVA-chanllege,
- GSE237260 Transcriptome Analysis Reveals Gene Expression Changes in a mouse Model of Hyperoxia-induced acute lung injury 12 samples shares changes, lung
- GSE296297 Single-cell gene expression profiles of mice lung tissue under PM2.5 exposure 26 samples shares lung
- GSE279918 Gene expression profile at single cell level of lungs of adult male and female C57BL/6 mice with andwithout high-fat diet-induced obesity 12 samples shares lung
- GSE325662 Gene expression profiling of lung tissue from LPS-induced acute lung injury mice treated with Renshen Baidu Powder 9 samples shares lung
- GSE226938 Early amyloid-induced changes in microglia gene expression in APP/PS1 mice [scRNA-seq] 36 samples shares changes
- GSE313869 Impact of Fc engineering on the transcriptional profile of monocytes and interstitial macrophages in the lungs of Hu-FcgR Tg mice after MA30 infection 36 samples shares lung
- GSE302019 Bulk RNA sequencing to investigate transcriptional profiles of lung macrophage subpopulations isolated from wild-type C57BL/6J and Spp1-EGFP knock-in reporter mice subjected to intratracheal administration of bleomycin or PBS. 24 samples shares lung
- GSE279813 Gene expression changes in skin of dihydrotestosterone-induced mice after treatment of a newly-developed traditional Chinese medicine formula, Hanlianxiang. 24 samples shares changes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.