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Numb-Ifi204 inhibits microglial activation and the hippocampal inflammation induced by LPS.

GSE295555 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/24 Platform GPL28330
Summary
This study aimed to identify the mechanisms regulating microglial activation and to explore potential therapeutic targets for neuroinflammation-related cognitive dysfunction disorders. We uncover a novel role for Numb in regulating microglial activation and highlight its interaction with Ifi204 in the LPS-induced TLR4 signaling pathway. We demonstrate that Numb promotes the autophagic degradation of Ifi204, thereby inhibiting the TLR4 signaling pathway and reducing excessive inflammatory responses in microglia. Furthermore, our findings show that Numb-mediated inhibition of microglial inflammation protects hippocampal neurons from synaptic damage, morphological abnormalities, and apoptosis.
Published in
Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia
Zhang S, Zang L, Li Y et al. · Neurobiology of disease 2026 · PMID 41962853 · doi:10.1016/j.nbd.2026.107386
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Also filed as BioProject PRJNA1255177 and SRA study SRP581077. Searching any of these in the dataset finder brings you back here.

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