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Persistence of alveolar fibroblast-derived ADAMTS4+ cells during delayed resolution of pulmonary fibrosis

GSE295566 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/02/20 Platform GPL24247
Summary
Idiopathic pulmonary fibrosis is a severe interstitial lung disease with limited therapeutic options. This study traced fibroblast growth factor 10 (Fgf10+) alveolar fibroblasts (AFs) in aged mice subjected to bleomycin injury, analyzing histology and single-cell transcriptomics at peak fibrosis and during resolution phases. Ex vivo models and human lung tissue data were also examined. Results showed Fgf10+ AFs transitioning from lipofibroblasts (LIF) to myofibroblasts (MyoFBs) during fibrogenesis, and reversing during resolution. An ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4+) AF population was linked to delayed resolution. ADAMTS4 emerged as a key target in fibrotic lung diseases, highlighting its therapeutic potential.
Published in
Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution
Zabihi M, Khadim A, Lingampally A et al. · Nature communications 2026 · PMID 42103706 · doi:10.1038/s41467-026-72419-3
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Also filed as BioProject PRJNA1255198 and SRA study SRP581133. Searching any of these in the dataset finder brings you back here.

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