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Exploring the dendritic cell subset regulating naïve CD8 T cell homeostasis

GSE295654 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2025/09/24 Platform GPL34290
Summary
The maintenance of naïve CD8 T cells within lymphoid organs is a finely tuned process involving multiple factors provided by stromal cells and antigen-presenting cells, particularly dendritic cells (DCs). In this study, we employed Cellular Indexing of Transcriptomes and Epitopes by sequencing (CITE-Seq) to comprehensively profile dendritic cell subsets and their potential roles in supporting naïve CD8 T cell homeostasis. By integrating transcriptomic and surface protein expression data, we identified distinct dendritic cell populations with specialized gene expression signatures and immunological features. These findings provide novel insights into the cellular and molecular mechanisms governing CD8 T cell maintenance, with implications for immune regulation and potential therapeutic strategies.
Published in
Integrin CD103 expression in naive CD8(+) T cells promotes cytokine-driven acquisition of memory phenotype and effector function
Li C, Ligons DL, Lanasa D et al. · Immunity 2025 · PMID 40957420 · doi:10.1016/j.immuni.2025.08.014
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Direct links to NCBI, no account and no request form: the whole study as GSE295654_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1255538 and SRA study SRP581283. Searching any of these in the dataset finder brings you back here.

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