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MiR-126-driven Vascular Remodeling of Aging Bone Marrow: A Correctable Cause of Age-related Loss of Hematopoietic Activity

GSE296123 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/06 Platform GPL24247
Summary
We describe here how inflammation-mediated depletion of miR-126 in endothelial cells (ECs) of aging bone marrow niche contributes to vascular remodeling and reduced supply of EC miR-126 to hematopoietic stem cells (HSCs) and causes age-related decrease of HSC self-renewal capacity.
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Also filed as BioProject PRJNA1257834 and SRA study SRP582618. Searching any of these in the dataset finder brings you back here.

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