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Kidney Effects of Immune Checkpoint Inhibitors on a Humanized Chimeric Mouse Model.

GSE296138 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/13 Platform GPL34290
Summary
We have employed a single cell sequencing approach using 10x Genomics scRNA-seq to study immune checkpoint inhibitor effects on kidney cells. Immune checkpoint inhibitors leads to break of immune tolerance and potential adverse related event. It is known that interstitial nephritis is most common presentation. Because exact mechanism is not clear this model wants to induce inflammation in a chimeric mouse. Evaluation of genes over or under expressed in differents groups of treatment by scRNA-seq would allow to understand better the dinamic of inflammation and identified potential targets.
Published in
TNF-α blockade mitigates immune checkpoint-related nephritis in a humanized mouse model
Cuenca Narvaez VD, Nava Chavez C, Al Refai O et al. · JCI insight 2026 · PMID 41785046 · doi:10.1172/jci.insight.199694
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Also filed as BioProject PRJNA1257857 and SRA study SRP582657. Searching any of these in the dataset finder brings you back here.

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