A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 11 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 3 × mTH17_WT vs 3 × mTH17_WT_FICZ vs 3 × mTH17_ZF7 vs 2 × mTH17_ZF7_FICZGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A20's linear ubiquitin-binding motif restrains pathogenic activation of Th17 cells and IL-22-driven enteritisThe Journal of clinical investigation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296200_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1258201 and SRA study SRP582845. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8966978 mTH17_WT_rep1 mTH17_WT
- GSM8966979 mTH17_WT_FICZ_rep1 mTH17_WT_FICZ
- GSM8966980 mTH17_ZF7_rep1 mTH17_ZF7
- GSM8966981 mTH17_ZF7_FICZ_rep1 mTH17_ZF7_FICZ
- GSM8966982 mTH17_WT_rep2 mTH17_WT
- GSM8966983 mTH17_WT_rep3 mTH17_WT
- GSM8966984 mTH17_WT_FICZ_rep2 mTH17_WT_FICZ
- GSM8966985 mTH17_WT_FICZ_rep3 mTH17_WT_FICZ
- GSM8966986 mTH17_ZF7_rep2 mTH17_ZF7
- GSM8966987 mTH17_ZF7_rep3 mTH17_ZF7
- GSM8966988 mTH17_ZF7_FICZ_rep2 mTH17_ZF7_FICZ
- GSE296201 A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis [RNA-Seq] 18 samples shares il-22, th17, a20, pathogenic, activation, ubiquitin, restrains, enteritis
- GSE318707 ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic Th1 and Th17 programs 18 samples shares th17, pathogenic, restrains
- GSE240205 A human STAT3 gain of function variant drives Th17 expansion and IL-22 dependent skin inflammation in a model of psoriasiform dermatitis 24 samples shares il-22, th17
- GSE284714 AMPK signaling downstream of adenosine 2A receptor represses Th17 cell pathogenicity through epigenetic and metabolic reprogramming. 15 samples shares th17, pathogenic
- GSE290297 Population RNA-seq from Th17 cells differentiated in vitro under pathogenic (Th17p) and non-pathogenic (Th17n) conditions with DHEA or EGCG 79 samples shares th17, pathogenic
- GSE285450 Fructose specifically exacerbates pathogenic-Th17 cell differentiation and autoimmune diseases through ROS-EGFR signal 18 samples shares th17, pathogenic
- GSE298306 Immune-responsive gene-1: The mitochondrial Key to Th17 Cell Pathogenicity in CNS Autoimmunity 18 samples shares th17, pathogenic
- GSE306371 Unconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases 16 samples shares th17, pathogenic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.