Limited Immune Perturbations in Mice Exposed to Sustained Low-Dose Ionizing Radiation
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 × CNL_LDR_UT vs 5 × CNL_LDR_10mGy vs 5 × CNL_LDR_100mGyGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296450_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1259391 and SRA study SRP583327. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 3 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9664545 CNL_LDR_UT_rep1 CNL_LDR_UT
- GSM9664546 CNL_LDR_UT_rep2 CNL_LDR_UT
- GSM9664547 CNL_LDR_UT_rep3 CNL_LDR_UT
- GSM9664548 CNL_LDR_UT_rep4 CNL_LDR_UT
- GSM9664549 CNL_LDR_UT_rep5 CNL_LDR_UT
- GSM9664550 CNL_LDR_10mGy_rep1 CNL_LDR_10mGy
- GSM9664551 CNL_LDR_10mGy_rep2 CNL_LDR_10mGy
- GSM9664552 CNL_LDR_10mGy_rep3 CNL_LDR_10mGy
- GSM9664553 CNL_LDR_10mGy_rep4 CNL_LDR_10mGy
- GSM9664554 CNL_LDR_10mGy_rep5 CNL_LDR_10mGy
- GSM9664555 CNL_LDR_100mGy_rep1 CNL_LDR_100mGy
- GSM9664556 CNL_LDR_100mGy_rep2 CNL_LDR_100mGy
- GSM9664557 CNL_LDR_100mGy_rep3 CNL_LDR_100mGy
- GSM9664558 CNL_LDR_100mGy_rep4 CNL_LDR_100mGy
- GSM9664559 CNL_LDR_100mGy_rep5 CNL_LDR_100mGy
- GSE268247 BIO 300 attenuates whole blood transcriptome changes in mice exposed to total-body radiation 60 samples shares radiation, exposed
- GSE244971 Transcriptome data of hematopoietic stem cells of mice under ionizing radiation 12 samples shares radiation, ionizing
- GSE255433 Effect of Low-dose-rate Radiation on Cognition and Gene Expression Profiles in Type II Diabetes Mellitus Mouse Model 12 samples shares radiation, low-dose
- GSE279340 Lycopene Ameliorates Ionizing Radiation-Induced Intestinal Injury 9 samples shares radiation, ionizing
- GSE298566 FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective 15 samples shares radiation
- GSE294347 Rationalistic Modulation of Immune Mechanisms Synergizes the Anti-Tumor Effects of Targeted Radiation Therapy in Pre-clinical Models 14 samples shares radiation
- GSE304809 Curative treatment of advanced, poorly immunogenic metastatic murine cancer models using an in situ vaccine, low-dose radiopharmaceutical, and immune checkpoint inhibition 14 samples shares low-dose
- GSE245747 Transcriptome Analysis in Mouse Skin After Exposure to Ultraviolet Radiation from a Canopy Sunbed 145 samples shares radiation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.