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Plaque-induced transcriptional reprogramming of microglia towards lymphoid receptor expression protects against Alzheimer's disease

GSE296523 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2025/08/07 Platform GPL17021
Summary
We have utilized a single nucleus sequencing approach using 10x Genomics snRNA-seq to understand the role of PU.1 expression level in the determination of microglia activation states relavent to Alzheimer's disease. Microglia have been shown to have both neuroprotective and neurotoxic functions during disease, however it remains to be understood how these states are regulated. This study provides new insights into the protective function of microglia mediated by a transcriptional shift toward lymphoid gene expression.
Published in
Lymphoid gene expression supports neuroprotective microglia function
Ayata P, Crowley JM, Challman MF et al. · Nature 2025 · PMID 41193812 · doi:10.1038/s41586-025-09662-z
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Also filed as BioProject PRJNA1259806 and SRA study SRP583532. Searching any of these in the dataset finder brings you back here.

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