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Visomitin attenuates pathological bone loss by reprogramming osteoclast metabolism via STAT3/LDHB axis

GSE296882 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/01 Platform GPL34290
Summary
A persistently substantial energy demand and metabolic reprogramming endure throughout the entire course of osteoclastogenesis, accompanied by an intensified oxidative stress. Hence, balancing cellular energy metabolism and mataining redox homeostasis offers potential for coordinating osteoclastogenesis and bone loss in pathological conditions. In the present study, we have discovered Visomitin, a novel antioxidant that specifically targets mitochondria, which efficiently decreases intracellular reactive oxygen species levels, inhibits osteoclastogenesis, and impairs bone resorption.
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Also filed as BioProject PRJNA1261879 and SRA study SRP584770. Searching any of these in the dataset finder brings you back here.

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