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A Novel Therapeutic Agent: Harnessing Macrophage Polarization to Combat Sepsis and Alleviate Lung Injury

GSE296887 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/12 Platform GPL24247
Summary
Sepsis is a complex syndrome characterized by dysregulated immune responses, with macrophage polarization being pivotal in its immunomodulation. Lung injury is a prevalent and severe consequence in sepsis. This research delved into the therapeutic potential of JSNPs. Initially, investigations involving bioinformatics analysis and JHU083 treatment revealed that while JHU083 extended septic mice's survival, it had limited impact on lung injury.Subsequently, studies on JSNPs showed it could improve sepsis and lung injury in CLP and LPS models. Mechanistically, JSNPs promoted macrophage polarization towards the anti - inflammatory M2 phenotype, safeguarding neurons from sepsis - induced lung injury. Further experiments demonstrated that JSNPs's protection of lung neurons was M2 macrophage dependent, and macrophages released neurotrophic factors under JSNPs's influence to shield neurons. Overall, JSNPs emerges as a promising candidate for treating sepsis and its associated lung injury.
Published in
Nanotherapeutic Macrophage-Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis-Induced Lung Injury and Neurologic Damage
Wang W, Hai Y, Lu X et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41698047 · doi:10.1002/advs.202520665
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Also filed as BioProject PRJNA1261887 and SRA study SRP584761. Searching any of these in the dataset finder brings you back here.

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