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H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (RNA-seq)

GSE296978 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/13 Platform GPL21103
Summary
We investigated the combined effects of H4K16 acylations in vivo using a mouse model of short-chain acyl-CoA dehydrogenase deficiency (SCADD), which causes metabolic challenges and systemic shifts in acyl-CoA ratios. Our findings indicate that H4K16 acylations modulate transcriptional responses in a concerted manner, providing insights into an adaptive chromatin regulation in response to metabolic stress.
Published in
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Nitsch S, Coraor AE, Schauer T et al. · Molecular cell 2026 · PMID 41421336 · doi:10.1016/j.molcel.2025.11.030
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Also filed as BioProject PRJNA1262312 and SRA study SRP584874. Searching any of these in the dataset finder brings you back here.

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