Senataxin Promotes RNA Polymerase II Elongation [Hap1_DRBrelease_TTseq]
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A role for human senataxin in contending with pausing and backtracking during transcript elongationMolecular cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297204_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1262997 and SRA study SRP585276. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8986068 Hap1_DRBR15m_DMSO_rep1 Hap1_DRBR15m_DMSO
- GSM8986069 Hap1_DRBR15m_DMSO_rep2 Hap1_DRBR15m_DMSO
- GSM8986070 Hap1_DRBR15m_DMSO_rep3 Hap1_DRBR15m_DMSO
- GSM8986071 Hap1_DRBR15m_dTAG_rep1 Hap1_DRBR15m_dTAG
- GSM8986072 Hap1_DRBR15m_dTAG_rep2 Hap1_DRBR15m_dTAG
- GSM8986073 Hap1_DRBR15m_dTAG_rep3 Hap1_DRBR15m_dTAG
- GSM8986074 Hap1_DRBR20m_DMSO_rep1 Hap1_DRBR20m_DMSO
- GSM8986075 Hap1_DRBR20m_DMSO_rep2 Hap1_DRBR20m_DMSO
- GSM8986076 Hap1_DRBR20m_DMSO_rep3 Hap1_DRBR20m_DMSO
- GSM8986077 Hap1_DRBR20m_dTAG_rep1 Hap1_DRBR20m_dTAG
- GSM8986078 Hap1_DRBR20m_dTAG_rep2 Hap1_DRBR20m_dTAG
- GSM8986079 Hap1_DRBR20m_dTAG_rep3 Hap1_DRBR20m_dTAG
- GSM8986080 Hap1_DRBR30m_DMSO_rep1 Hap1_DRBR30m_DMSO
- GSM8986081 Hap1_DRBR30m_DMSO_rep2 Hap1_DRBR30m_DMSO
- GSM8986082 Hap1_DRBR30m_DMSO_rep3 Hap1_DRBR30m_DMSO
- GSM8986083 Hap1_DRBR30m_dTAG_rep1 Hap1_DRBR30m_dTAG
- GSM8986084 Hap1_DRBR30m_dTAG_rep2 Hap1_DRBR30m_dTAG
- GSM8986085 Hap1_DRBR30m_dTAG_rep3 Hap1_DRBR30m_dTAG
- GSE280102 A CDK11-dependent RNA polymerase II pause-release checkpoint precedes CDK9-mediated transition to transcriptional elongation [RNA-seq] 29 samples shares polymerase, elongation
- GSE294526 The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma [RNA-seq II] 21 samples shares elongation, promotes
- GSE292860 Selective CDK7 Inhibition Sensitizes Tumors to Topoisomerase I Inhibitor-Antibody Drug Conjugates by Blocking The Transition of The RNA polymerase II Initiation Complex into Elongation [RNA-seq] 16 samples shares polymerase, elongation
- GSE281924 PAF1C-dependent activation of CDK12 is required for RNA polymerase II phosphorylation and transcript elongation 15 samples shares polymerase, elongation
- GSE273681 NDF-FACT phase separation condensates are required for RNA Polymerase II transcription elongation through chromatin [RNA-Seq] 12 samples shares polymerase, elongation
- GSE265884 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (RNA-Seq) 10 samples shares polymerase, elongation
- GSE218269 CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release 100 samples shares polymerase, promotes
- GSE292907 Selective CDK7 Inhibition Sensitizes Tumors to Topoisomerase I Inhibitor-Antibody Drug Conjugates by Blocking The Transition of The RNA polymerase II Initiation Complex into Elongation [ChIP-seq] 97 samples shares polymerase, elongation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.