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Nutritional c-Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity-Associated Hepatocellular Carcinoma

GSE297224 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/01 Platform GPL34290
Summary
The transcription factor c-Fos plays an important role in hepatic metabolism. Previous studies implicated the c-Fos/AP-1 in steatohepatitis development and hepatocellular carcinoma formation. However, its role in metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma remains to be illustrated. Here, we analyse the transcriptional consequences of adenovirus-mediated c-Fos silencing in the liver of young adult mice during 2 weeks by bulk RNA-seq.
Published in
Nutritional c-Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity-Associated Hepatocellular Carcinoma
Li A, Gilglioni EH, St-Pierre-Wijckmans W et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 41024433 · doi:10.1002/advs.202509755
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Also filed as BioProject PRJNA1263189 and SRA study SRP585495. Searching any of these in the dataset finder brings you back here.

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