Polyploid cisplatin-resistant cancer cells have altered nuclear organization and epigenomic status
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Polyploid cisplatin-resistant cancer cells have altered nuclear organization and epigenomic statusNeoplasia (New York, N.Y.) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297299_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1263486 and SRA study SRP585605. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8988048 Parse sequencing, PC3cisplatin sublibrary1 (contains all samples)
- GSM8988049 Parse sequencing, PC3cisplatin sublibrary2 (contains all samples)
- GSM8988050 Parse sequencing, PC3cisplatin sublibrary3 (contains all samples)
- GSM8988051 Parse sequencing, PC3cisplatin sublibrary4 (contains all samples)
- GSM8988052 Parse sequencing, PC3cisplatin sublibrary5 (contains all samples)
- GSM8988053 Parse sequencing, PC3cisplatin sublibrary6 (contains all samples)
- GSM8988054 Parse sequencing, PC3cisplatin sublibrary7 (contains all samples)
- GSM8988055 Parse sequencing, PC3cisplatin sublibrary8 (contains all samples)
- GSM8988056 Parse sequencing, PC3docetaxel sublibrary1 (contains all samples)
- GSM8988057 Parse sequencing, PC3docetaxel sublibrary2 (contains all samples)
- GSM8988058 Parse sequencing, PC3docetaxel sublibrary3 (contains all samples)
- GSM8988059 Parse sequencing, PC3docetaxel sublibrary4 (contains all samples)
- GSM8988060 Parse sequencing, PC3docetaxel sublibrary5 (contains all samples)
- GSM8988061 Parse sequencing, PC3docetaxel sublibrary6 (contains all samples)
- GSM8988062 Parse sequencing, PC3docetaxel sublibrary7 (contains all samples)
- GSM8988063 Parse sequencing, PC3docetaxel sublibrary8 (contains all samples)
- GSE289252 Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity 46 samples shares organization, nuclear
- GSE270568 Polyploid cancer cells reveal signatures of chemotherapy relapse [scRNA-seq] 605 samples shares polyploid
- GSE256188 Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer 36 samples shares organization
- GSE296927 The Notch ligand Jagged1 regulates extracellular matrix production and organization in triple-negative breast cancer 18 samples shares organization
- GSE294934 Epigenomic analysis of organoids from colorectal cancer peritoneal and liver metastases uncovers a mechanism of resistance to doxorubicin 15 samples shares epigenomic
- GSE290040 single-cell spatial analysis reveals molecular mechanisms underlying immune cell organization and cancer cell heterogeneity in HPV-associated oropharyngeal carcinoma 15 samples shares organization
- GSE292004 OCT-2 is associated with pro-metastatic epigenomic properties of triple-negative breast cancer cells 12 samples shares epigenomic
- GSE318552 Early events in transcription and genome organization after STAG2 reconstitution in human cancer cells [RNA-Seq] 12 samples shares organization
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.