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Follicular mural granulosa cells stockpile glycogen to fuel corpus luteum pre-vascularization

GSE297300 Mus musculus Expression profiling by high throughput sequencing 3 samples Submitted 2026/02/14 Platform GPL24247
Summary
The differentiation of follicular mural granulosa cells (fGCs) into luteal cells involves a rapid progesterone synthesis surge and the vascular network development. However, progesterone elevation occurs before vascularization, leaving luteinizing fGCs temporarily devoid of blood supply. The mechanism of how fGCs fuel increased progesterone synthesis during this avascular phase remains unclear. Our research, utilizing single-cell RNAseq and in vivo/ex vivo experiments, revealed that upon receiving the ovulatory/luteinization signal, fGCs transition to a low-energy state, reducing metabolic activity and storing glucose as glycogen.
Published in
Fosl2 Regulates FSH-Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling
Shi H, Chen C, Ran Z et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41955481 · doi:10.1002/advs.75223
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Also filed as BioProject PRJNA1263481 and SRA study SRP585593. Searching any of these in the dataset finder brings you back here.

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