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RNA-Seq of T26-treated and untreated MC38 cell

GSE297452 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/06 Platform GPL24247
Summary
This study investigates the transcriptional changes in murine colon adenocarcinoma MC38 cells in response to treatment with T26, a novel compound designed to modulate glutamine metabolism and immune-related pathways. RNA sequencing (RNA-Seq) was performed to compare the transcriptomic profiles of MC38 cells treated with T26 versus untreated controls. Differentially expressed genes were analyzed to elucidate the molecular mechanisms underlying T26-mediated anti-tumor activity. This dataset provides a resource for understanding how T26 impacts tumor cell-intrinsic gene expression and may inform its potential role in cancer immunotherapy.
Published in
Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine-Driven Immune Suppression in Colorectal Cancer
Zhang B, Fan R, Hai Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41173791 · doi:10.1002/advs.202513986
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Direct links to NCBI, no account and no request form: the whole study as GSE297452_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1263868 and SRA study SRP585958. Searching any of these in the dataset finder brings you back here.

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