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IRE1signaling in Osx1-cre expressing cells

GSE297458 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/01/22 Platform GPL19057
Summary
The Unfolded Protein Response (UPR) fine tunes the protein folding capacity of the endoplasmic reticulum (ER) in eukaryotic cells via the actions of PERK, IRE1 and ATF6 proteins. However, the specific contributions of these proteins to bone health have not been investigated. These studies evaluated the role of IRE1 signlaing in preosteoblasts by condcting studies in osteoprogenitors lacking IRE1 (generated via Osx1-cre). The studies invovled isolation and culture of IRE1KO and flox control osteoprogenitor cells that gene expression analysis. Our studies reveal a novel regulatory role in stimulating osteoprogenitor proliferation by stimulating β-catenin/TCF mediated transcription and subsequent bone formation
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Also filed as BioProject PRJNA1263882 and SRA study SRP585977. Searching any of these in the dataset finder brings you back here.

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