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Impact of AIM2 on Head and Neck Squamous Cell Carcinoma Development

GSE297487 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/10 Platform GPL24247
Summary
Head and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation through mechanisms that are not fully understood. The cytosolic double-stranded DNA sensor Absent in Melanoma 2 (AIM2) is an inflammasome-forming protein that also has inflammasome-distinct roles in restricting tumorigenesis. We performed bulk RNA sequencing on tongue tissue from wild type (WT) and Aim2-/- mice treated with the carcinogen 4NQO in drinking water as a model of experimental HNSCC to uncover gene signatures regulated by AIM2 during HNSCC development.
Published in
Impact of absent in melanoma 2 on head and neck squamous cell carcinoma development
Reinartz DM, Escamilla-Rivera V, Shao M et al. · Journal of immunology (Baltimore, Md. : 1950) 2025 · PMID 41042265 · doi:10.1093/jimmun/vkaf224
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Also filed as BioProject PRJNA1265067 and SRA study SRP586231. Searching any of these in the dataset finder brings you back here.

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