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Bacterial ADP-Heptose triggers stem cell regeneration in the intestinal epithelium following injury [scRNA-seq]

GSE297524 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/18 Platform GPL24247
Summary
ADP-Heptose (ADP-Hep), a metabolite produced by Gram-negative bacteria as an intermediate of lipopolysaccharide biosynthesis, is detected in the host cytosol by the kinase ALPK1, which engages TIFA-dependent innate immune responses. However, the functional role of the ALPK1-TIFA pathway in the intestinal epithelium remains poorly understood. Here, we use bulk RNA sequencing of murine derived ileal organoids to study the role of ADP-Hep in initiating stem cell regeneration in the intestinal epithelium.
Published in
Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury
Goyal S, Guo CX, Singh O et al. · Cell stem cell 2025 · PMID 40651470 · doi:10.1016/j.stem.2025.06.009
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Also filed as BioProject PRJNA1265136 and SRA study SRP586466. Searching any of these in the dataset finder brings you back here.

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