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iCLIP analysis of full-length and deletion mutants of myc-LARP6

GSE297587 Homo sapiens (human) RNA-seq (gene expression) 30 samples Submitted 2026/01/22 Platform GPL18573Platform GPL34284
At a glance

RNA-seq (gene expression) · human · 30 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
30 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6Nature communications · 2026
Summary (written by the submitters)
Intrinsically disordered regions (IDRs) are prevalent in RNA-binding proteins (RBPs), yet their roles in RNA interactions remain poorly defined. We examined the structured and disordered RNA-binding activities of LARP6, an RBP with a diverse RNA-binding repertoire.
Read the full summary ↓
U87 glioblastoma cells stably expressing myc-tagged full-length or various deletion mutants of LARP6 under a doxycycline switch were induced to express myc-LARP6 variants at near endogenous levels, before individual-nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP) was performed to assess each variants' RNA-binding targets on the transcriptome. A total RNA-seq experiment was also performed on the cells in parallel to distinguish between changes in RNA bidning and those that are affected via expression level variations.
Published in
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6
Capraro F, Abis G, Incocciati A et al. · Nature communications 2026 · PMID 41714637 · doi:10.1038/s41467-026-69789-z
This dataset
Open GSE297587 in finder → Find more human datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297587_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1265224 and SRA study SRP586368. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41714637) ↗
Study design
6 conditions, mostly in triplicate
U87 Control ×3 Full-length mycLARP6 ×3 deltaNTR mycLARP6 ×3 deltaNTD mycLARP6 ×3 deltaLa-Mod mycLARP6 ×3 deltaCTR mycLARP6 ×3 U87 Control-INPUT_smallRNAseq ×1 U87 Control-INPUT_longRNAseq ×1 +10 more

Supports a between-group comparison across 18 samples.

How we read this: 6 replicated groups read from 30 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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