Mesenchymal Stem Cell Extracellular Vesicles Ameliorate Radiation-caused Dry Mouth
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolismStem cell research & therapy · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297762_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1266141 and SRA study SRP586956. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8999070 SMG, nontreated, rep1 SMG, nontreated,
- GSM8999071 SMG, nontreated, rep2 SMG, nontreated,
- GSM8999072 SMG, nontreated, rep3 SMG, nontreated,
- GSM8999073 SMG, IR day 4, rep1 SMG, IR day 4,
- GSM8999074 SMG, IR day 4, rep2 SMG, IR day 4,
- GSM8999075 SMG, IR day 4, rep3 SMG, IR day 4,
- GSM8999076 SMG, IR + iEVs day 4, rep1 SMG, IR + iEVs day 4,
- GSM8999077 SMG, IR + iEVs day 4, rep2 SMG, IR + iEVs day 4,
- GSM8999078 SMG, IR + iEVs day 4, rep3 SMG, IR + iEVs day 4,
- GSM8999079 SMG, IR day 30, rep1 SMG, IR day 30,
- GSM8999080 SMG, IR day 30, rep2 SMG, IR day 30,
- GSM8999081 SMG, IR day 30, rep3 SMG, IR day 30,
- GSM8999082 SMG, IR + iEVs day 30, rep1 SMG, IR + iEVs day 30,
- GSM8999083 SMG, IR + iEVs day 30, rep2 SMG, IR + iEVs day 30,
- GSM8999084 SMG, IR + iEVs day 30, rep3 SMG, IR + iEVs day 30,
- GSE272476 Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells [RNA-seq] 30 samples shares extracellular, mesenchymal, vesicles, stem
- GSE295428 Spaceflight induces systemic effects on extracellular matrix and immune system in different age-stages 229 samples shares extracellular, stem
- GSE330865 Multiorgan transcriptomics and circulating extracellular vesicle profiling reveal age-dependent systemic vulnerability to isoflurane anesthesia and surgery 120 samples shares extracellular, stem
- GSE242731 Class switch recombination regulation by extracellular vesicles mediated intercellular epigenomic signaling 48 samples shares extracellular, vesicles
- GSE273883 CX3CR1+ Synovial Macrophages for Barrier Restore in Rheumatoid Arthritis: A New Target for Mesenchymal Stem Cell-Based Therapy? 35 samples shares mesenchymal, stem
- GSE282285 Aged muscle stem cells epigenetically drive the expansion of mesenchymal progenitors [bulk RNA-Seq] 31 samples shares mesenchymal, stem
- GSE327752 Human breast milk-derived extracellular vesicles alleviate Alzheimer’s disease phenotypes through delivering CD36 18 samples shares extracellular, vesicles
- GSE243611 Human Brain Small Extracellular Vesicles Contain Selectively-Packaged, Full-Length mRNA 18 samples shares extracellular, vesicles
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.