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RNA-seq analysis of MLO-Y4 cells under hypoxic conditions

GSE298138 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/30 Platform GPL24247
Summary
To investigate the effects of hypoxia on osteocytes, we cultured MLO-Y4 osteocytic cells under normoxic (20% O₂) and hypoxic (2% O₂) conditions. We then performed gene expression profiling analysis using RNA-seq data obtained from these cells. Differential expression analysis revealed that Lipocalin 2 (LCN2) was one of the most significantly upregulated genes under hypoxic conditions.The dataset provides insights into the transcriptional response of osteocytes to hypoxic stress.
Published in
Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis
Narita K, Ohori F, Marahleh A et al. · Scientific reports 2026 · PMID 41495150 · doi:10.1038/s41598-025-34575-2
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Also filed as BioProject PRJNA1268425 and SRA study SRP588126. Searching any of these in the dataset finder brings you back here.

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