CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection
RNA-seq (gene expression) · mouse · 54 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 54 samples: 18 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298176_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1268468 and SRA study SRP586296. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 54 samples.
How we read this: 18 replicated groups read from 54 sample titles; they account for 54 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8993851 FKO_C1 FKO_C
- GSM8993852 FKO_C2 FKO_C
- GSM8993853 FKO_C3 FKO_C
- GSM8993854 FKO_T1 FKO_T
- GSM8993855 FKO_T2 FKO_T
- GSM8993856 FKO_T3 FKO_T
- GSM8993857 FWT_C1 FWT_C
- GSM8993858 FWT_C2 FWT_C
- GSM8993859 FWT_C3 FWT_C
- GSM8993860 FWT_T1 FWT_T
- GSM8993861 FWT_T2 FWT_T
- GSM8993862 FWT_T3 FWT_T
- GSM8993863 KO-C1 KO-C
- GSM8993864 KO-C2 KO-C
- GSM8993865 KO-C3 KO-C
- GSM8993866 KO_T1 KO_T
- GSM8993867 KO_T2 KO_T
- GSM8993868 KO_T3 KO_T
- GSM8993869 WT_C1 WT_C
- GSM8993870 WT_C2 WT_C
- GSM8993871 WT_C3 WT_C
- GSM8993872 WT_T1 WT_T
- GSM8993873 WT_T2 WT_T
- GSM8993874 WT_T3 WT_T
- GSM8993875 A_0_1 A_0
- GSM8993876 A_0_2 A_0
- GSM8993877 A_0_3 A_0
- GSM8993878 A_R_1 A
- GSM8993879 A_R_2 A
- GSM8993880 A_R_3 A
- GSM8993881 WT_C_0_0_1 WT_C_0_0
- GSM8993882 WT_C_0_0_2 WT_C_0_0
- GSM8993883 WT_C_0_0_3 WT_C_0_0
- GSM8993884 WT_T_0_R_1 WT_T_0
- GSM8993885 WT_T_0_R_2 WT_T_0
- GSM8993886 WT_T_0_R_3 WT_T_0
- GSM8993887 R26_0_1 R26_0
- GSM8993888 R26_0_2 R26_0
- GSM8993889 R26_0_3 R26_0
- GSM8993890 R26_R_1 R26
+ 14 more — browse all 54 samples with per-sample file links →
- GSE234245 Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target [RNA-Seq] 79 samples shares therapeutic, target
- GSE280699 The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age [RNA-seq] 78 samples shares therapeutic, target
- GSE325852 Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target 69 samples shares therapeutic, target
- GSE301751 Therapeutic Efficacy, Biomarker Signatures and Translatability of Semaglutide in the Liver Biopsy-Confirmed GAN DIO-MASH Mouse Model (study 7/9) 53 samples shares therapeutic, biomarker
- GSE325548 Time-resolved transcriptomic profiling of surgical wounds identifies stage-specific therapeutic targets for residual ovarian cancer 48 samples shares therapeutic, target
- GSE325608 Transcriptome Sequencing of BAPN-Induced Aortic Dissection in Male and Female Mice 48 samples shares dissection, aortic
- GSE280580 PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination 33 samples shares therapeutic, target
- GSE248272 Therapeutically targeting perivascular macrophage effector function improves CD8+ T-cell infiltration and response to chemotherapeutic drugs in cancer 30 samples shares therapeutic, target
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.