GEO series
METTL3-dependent m6A methylation in atherogenic endothelial inflammation [RNA]
GSE298180
Homo sapiens
Expression profiling by high throughput sequencing
9 samples
2026/06/26
GPL16791
Summary
Atherosclerosis is initiated by endothelial inflammation. Using RNA-seq and eCLIP, we identified METTL3 as a mechanosensitive m6A writer that upregulates NLRP1 and downregulates KLF4 through YTHDF readers. Knockdown of METTL3 abrogated these changes and protected against flow-induced atherogenesis in vitro and in vivo.
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