METTL3-dependent m6A RNA methylation regulates activation of the NLRP3 inflammasome
DNA methylation · human · 18 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 9 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE216483_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA893677 and SRA study SRP404419. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 9 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6673872 Ath DMSO1 Ath DMSO
- GSM6673873 Ath DMSO2 Ath DMSO
- GSM6673874 Ath Nig1 Ath Nig
- GSM6673875 Ath Nig2 Ath Nig
- GSM6673876 M3sh1 Nig1 M3sh1 Nig
- GSM6673877 M3sh1 Nig2 M3sh1 Nig
- GSM6674687 INP_Ath_DMSO1 INP_Ath_DMSO
- GSM6674688 INP_Ath_DMSO2 INP_Ath_DMSO
- GSM6674689 INP_Ath_Nig1 INP_Ath_Nig
- GSM6674690 INP_Ath_Nig2 INP_Ath_Nig
- GSM6674691 INP_M3Sh1_Nig1 INP_M3Sh1_Nig
- GSM6674692 INP_M3Sh1_Nig2 INP_M3Sh1_Nig
- GSM6674693 IP_Ath_DMSO1 IP_Ath_DMSO
- GSM6674694 IP_Ath_DMSO2 IP_Ath_DMSO
- GSM6674695 IP_Ath_Nig1 IP_Ath_Nig
- GSM6674696 IP_Ath_Nig2 IP_Ath_Nig
- GSM6674697 IP_M3Sh1_Nig1 IP_M3Sh1_Nig
- GSM6674698 IP_M3Sh1_Nig2 IP_M3Sh1_Nig
- GSE275738 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells 72 samples shares mettl3-dependent, methylation
- GSE274217 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells [RNA-Seq] 28 samples shares mettl3-dependent, methylation
- GSE308630 Molecular Mechanisms of the MLL4 Complex in H3K4 Methylation and p53-Dependent Transcription Activation 26 samples shares methylation, activation
- GSE293474 KMT2D-Mediated H3K4methylation is Essential for GATA1 Transcriptional Activation in Erythropoiesis [ChIP-seq] 24 samples shares methylation, activation
- GSE282206 NLRP1 inflammasome activation in skin equivalents reveals mechanistic insights into the roles of keratinocytes in psoriasis 24 samples shares inflammasome, activation
- GSE302851 Methylation variability and LINE-1 activation in multiple myeloma 23 samples shares methylation, activation
- GSE275737 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells [ChIP-Seq] 21 samples shares mettl3-dependent, methylation
- GSE298180 METTL3-dependent m6A methylation in atherogenic endothelial inflammation [RNA] 9 samples shares mettl3-dependent, methylation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.