Oxidised LDL induces pro-inflammatory transcriptomic and epigenomic responses in human CD4+ T cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Oxidized LDL Induces Pro-Inflammatory Transcriptomic and Epigenomic Responses in Human CD4(+) T CellsFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298362_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1269019. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9001727 CD4 Donor 1 Buffer ATAC-seq
- GSM9001728 CD4 Donor 2 Buffer ATAC-seq
- GSM9001729 CD4 Donor 3 Buffer ATAC-seq
- GSM9001730 CD4 Donor 1 oxLDL ATAC-seq
- GSM9001731 CD4 Donor 2 oxLDL ATAC-seq
- GSM9001732 CD4 Donor 3 oxLDL ATAC-seq
- GSM9001733 CD4 Donor 1 Buffer RNA-seq
- GSM9001734 CD4 Donor 2 Buffer RNA-seq
- GSM9001735 CD4 Donor 3 Buffer RNA-seq
- GSM9001736 CD4 Donor 1 oxLDL RNA-seq
- GSM9001737 CD4 Donor 2 oxLDL RNA-seq
- GSM9001738 CD4 Donor 3 oxLDL RNA-seq
- GSM9001739 CD4 Donor 1 oxLDL H3K27ac ChIP-seq
- GSM9001740 CD4 Donor 1 Buffer H3K27ac ChIP-seq
- GSM9001741 CD4 Donor 1 Input Control H3K27ac ChIP-seq
- GSE324815 Intratumoral CD40 agonist sotigalimab in combination with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: Results of a phase 1/2 study 24 samples shares cd4, induces
- GSE271543 UCPVax, a CD4 helper peptide vaccine induces polyfunctional Th1 cells, antibody response and epitope spreading to improve antitumor immunity [scRNA-seq] 5 samples shares cd4, induces
- GSE280714 The role of RUNX2 and BHLHE40 in pathologically relevant CD4-positive tissue-resident T-cells in Crohn's disease. (scMultiome) 12 samples shares cd4
- GSE267774 Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis 3076 samples shares cd4
- GSE242232 Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases 928 samples shares cd4
- GSE291286 Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses 98 samples shares cd4
- GSE314342 Genome-scale perturb-seq in primary human CD4+ T cells reveals genes regulating T cell programs and human immune traits. 577 samples shares cd4
- GSE314188 Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes 514 samples shares cd4
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.