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The SIRT6-TDO2/KYNA-mTOR Axis Mediates Synaptic Plasticity and Cognitive Impairments in Fetal Growth Restriction Offspring

GSE298372 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/06/04 Platform GPL24247
Summary
Fetal growth restriction (FGR) can lead to cognitive impairment in offspring, but the underlying mechanisms remain unclear. This study found that hippocampal excitatory neurons in FGR mice exhibit significantly reduced SIRT6 expression. SIRT6 deficiency upregulates TDO2 via its histone deacetylase activity (independent of ADP-ribosyltransferase function), promoting kynurenic acid (KYNA) accumulation, which suppresses the AKT/mTOR/p70S6K pathway and disrupts synaptic protein synthesis.
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Also filed as BioProject PRJNA1269035 and SRA study SRP588303. Searching any of these in the dataset finder brings you back here.

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