Transcriptomic Characterization of Liver Tissue Changes in Human and Mice with Acute-on-Chronic Liver Failure and Liver Cirrhosis/Fibrosis
RNA-seq (gene expression) · mouse · 76 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 76 samples: 8 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cross-species hepatic transcriptomics identify conserved immune-metabolic reprogramming in acute-on-chronic liver failure progressionFrontiers in immunology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298435_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1269436 and SRA study SRP588762. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 59 samples.
How we read this: 8 replicated groups read from 76 sample titles; they account for 59 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9014182 HC1 HC
- GSM9014183 HC2 HC
- GSM9014184 HC3 HC
- GSM9014185 HC4-1
- GSM9014186 HC6 HC
- GSM9014187 HC7 HC
- GSM9014188 HC8-1
- GSM9014189 HC9-1
- GSM9014190 HC10-1
- GSM9014191 HC11-1
- GSM9014192 HC12-1
- GSM9014193 HC13-1
- GSM9014194 HC14-1
- GSM9014195 HC15-1
- GSM9014196 CLD1 CLD
- GSM9014197 CLD2 CLD
- GSM9014198 CLD3 CLD
- GSM9014199 CLD4-1
- GSM9014200 CLD5 CLD
- GSM9014201 CLD6 CLD
- GSM9014202 CLD7 CLD
- GSM9014203 CLD8 CLD
- GSM9014204 CLD9 CLD
- GSM9014205 CLD10 CLD
- GSM9014206 CLD11 CLD
- GSM9014207 CLD12 CLD
- GSM9014208 CLD13 CLD
- GSM9014209 CLD14 CLD
- GSM9014210 CLD14-1
- GSM9014211 CLD15 CLD
- GSM9014212 CLD16 CLD
- GSM9014213 ACLF1 ACLF
- GSM9014214 ACLF2 ACLF
- GSM9014215 ACLF3 ACLF
- GSM9014216 ACLF5 ACLF
- GSM9014217 ACLF6 ACLF
- GSM9014218 ACLF7 ACLF
- GSM9014219 ACLF8-1
- GSM9014220 ACLF9 ACLF
- GSM9014221 ACLF11 ACLF
+ 36 more — browse all 76 samples with per-sample file links →
- GSE136103 Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics 26 samples shares cirrhosis, liver
- GSE267145 The transcription factor ZNF469 regulates collagen production in liver fibrosis 508 samples shares fibrosis, liver
- GSE300053 Phase separation of endothelial PML drives inflammatory macrophage infiltration during liver fibrosis 69 samples shares fibrosis, liver
- GSE309745 Single-cell and single-nucleus transcriptomic profiling of mouse models and human lung tissues to study pulmonary fibrosis 54 samples shares fibrosis
- GSE296513 Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis 45 samples shares fibrosis
- GSE294753 Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis 24 samples shares fibrosis
- GSE212837 An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in non-alcoholic steatohepatitis 20 samples shares fibrosis
- GSE324714 Acquired genetic and cell state changes in IDH-mutant glioma progression [coculture experiments] 16 samples shares changes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.