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The transcription factor ZNF469 regulates collagen production in liver fibrosis

GSE267145 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 508 samples Submitted 2025/02/27 Platform GPL24247Platform GPL24676
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 508 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
508 samples: 306 distinct titles, 27 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
The transcription factor ZNF469 regulates collagen production in liver fibrosisJCI insight · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
The transcription factor ZNF469 regulates collagen production in liver fibrosis
Steinhauser S, Estoppey D, Buehler DP et al. · JCI insight 2025 · PMID 39998893 · doi:10.1172/jci.insight.182232
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267145_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1109849 and SRA study SRP505882. Searching any of these in the dataset finder brings you back here.

Study design
306 distinct titles, 27 of them repeated
FFD_mouse ×12 FFD_Ctrl_mouse ×12 MCD_Ctrl_mouse ×12 MCD_mouse ×12 OBOB_Fibrotic_mouse ×6 OBOB_FLO_mouse ×6 HSC001_hNTO_12day ×3 HSC001_COL1A1_12day ×3 +19 more

How we read this: Read from the first 400 of 508 sample titles: 306 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 468 more — browse all 508 samples with per-sample file links →

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