← BioTransfer GEO Dataset Finder
GEO series

GNAS/PKA pathway promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors

GSE298748 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/28 Platform GPL23479
Summary
We have employed a single cell sequencing approach using 10x Genomics scRNAseq to study the identity and fate determination of Gli1+ tendon sheath progenitors in heterotopic ossification(HO) formation following tenotomy. Gli1 is a signature gene for several tissue-specific Mesenchymal stem cells (MSCs). Aberrant osteochondral differentiation of MSCs in soft tissues leads to incorrect tissue regeneration into HO. This study demonstrated a subpopulation of Gli1+ tendon sheath cells that function as tendon stem/progenitors and can initially differentiate into normal or osteochondral tendon-lineage progenitors, with the latter subsequently giving rise to chondrocytes and osteocytes in development of tendon HO.
Published in
GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1(+) tendon sheath progenitors
Chen L, Peng C, Chai L et al. · The EMBO journal 2025 · PMID 40890486 · doi:10.1038/s44318-025-00553-7
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE298748_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1271048 and SRA study SRP589313. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.