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Maternal gut microbial legacy shapes intestinal health and colitis susceptibility of offspring

GSE298759 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/18 Platform GPL34328
Summary
Offspring born to mothers with colitis exhibited gut microbial dysbiosis, impaired barrier function, low-grade intestinal inflammation, compromised Wnt signaling and reduced crypt cell proliferation, which collectively increased their susceptibility to colitis in adulthood.
Published in
Maternal gut microbial legacy shapes intestinal health and susceptibility of offspring to colitis
Lee JM, Kim MJ, Lee H et al. · NPJ biofilms and microbiomes 2026 · PMID 41720783 · doi:10.1038/s41522-026-00938-4
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Also filed as BioProject PRJNA1271060 and SRA study SRP589301. Searching any of these in the dataset finder brings you back here.

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