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Effects on renal senescence, copper flux and respiration during stem cell-based therapy

GSE299500 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/06/18 Platform GPL24247
Summary
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) can reverse senescence after acute kidney injury (AKI) via maintaining mitochondrial homeostasis. Copper accumulation could promote senescence, but its response to MSCs remains unclear. C57 mice with renal unilateral ischemia reperfusion injury (uIRI) were renal capsular transplanted with hUC-MSCs for two weeks then performed mRNA sequencing. Gene correlation analysis revealed that senescence regulation is associated with copper homeostasis and respiratory chain complex IV.
Published in
MSCs-derived HGF alleviates senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration
Zhuang K, Wang W, Xu C et al. · Stem cell research & therapy 2025 · PMID 41024282 · doi:10.1186/s13287-025-04653-3
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Also filed as BioProject PRJNA1274853 and SRA study SRP591495. Searching any of these in the dataset finder brings you back here.

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