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mRNA profiling upon knockdown of circRNA-HIPK2

GSE299505 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/16 Platform GPL13112
Summary
Despite advances in drug development, global mortality rates following heart failure (HF) remain still high, underscoring the critical need for novel therapeutic strategies. Emerging evidence highlights cardiac macrophages as promising cellular targets for intervention. In our investigation, we identified a circular RNA-HIPK2 (circHIPK2.) exhibiting close association with macrophage polarization dynamics following myocardial infarction (MI). To elucidate its functional significance and associated transcriptomic alterations, we performed targeted knockdown of circHIPK2. in macrophage cells through siRNA transfection, comparing experimental groups (circHIPK2 siR) with controls (ctrl siR).
Published in
Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction
Jung M, Schmidt A, Sansonetti M et al. · European heart journal 2026 · PMID 41667113 · doi:10.1093/eurheartj/ehaf1116
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Also filed as BioProject PRJNA1274870 and SRA study SRP591487. Searching any of these in the dataset finder brings you back here.

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