Entospletinib modulates spatial gene expression in kidney immune microenvironments during injury and repair
Spatial transcriptomics · mouse · 94 samples
- What it is
- Spatial transcriptomicsGene activity measured with its position in a tissue section.
- Organism
- Mus musculus (mouse)
- Samples
- 94 samples: 36 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The spleen tyrosine kinase inhibitor entospletinib resolves inflammation to promote repair following acute kidney injuryJCI insight · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299516_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Spatial studies usually ship Space Ranger style folders (count matrix plus tissue images). Look for them among the supplementary files.
Also filed as BioProject PRJNA1274891 and SRA study SRP591488. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 72 samples.
How we read this: 36 replicated groups read from 94 sample titles; they account for 72 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9040183 E1-CTRL-M-IBA1-001
- GSM9040184 E1-CTRL-M-PanCK-001
- GSM9040185 E1-CTRL-C-IBA1-002 E1-CTRL-C-IBA1
- GSM9040186 E1-CTRL-C-PanCK-002 E1-CTRL-C-PanCK
- GSM9040187 E1-CTRL-C-IBA1-003 E1-CTRL-C-IBA1
- GSM9040188 E1-CTRL-C-PanCK-003 E1-CTRL-C-PanCK
- GSM9040189 E1-I1V-C-IBA1-004 E1-I1V-C-IBA1
- GSM9040190 E1-I1V-C-PanCK-004 E1-I1V-C-PanCK
- GSM9040191 E1-I1V-M-IBA1-005
- GSM9040192 E1-I1V-M-PanCK-005
- GSM9040193 E1-I1V-C-IBA1-006 E1-I1V-C-IBA1
- GSM9040194 E1-I1V-C-PanCK-006 E1-I1V-C-PanCK
- GSM9040195 E1-I1E-C-IBA1-007 E1-I1E-C-IBA1
- GSM9040196 E1-I1E-C-PanCK-007 E1-I1E-C-PanCK
- GSM9040197 E1-I1E-C-PanCK-007a
- GSM9040198 E1-I1E-M-IBA1-008
- GSM9040199 E1-I1E-M-PanCK-008
- GSM9040200 E1-I1E-C-IBA1-009 E1-I1E-C-IBA1
- GSM9040201 E1-I1E-C-PanCK-009 E1-I1E-C-PanCK
- GSM9040202 E1-I7V-M-IBA1-010
- GSM9040203 E1-I7V-M-PanCK-010
- GSM9040204 E1-I7V-C-IBA1-011 E1-I7V-C-IBA1
- GSM9040205 E1-I7V-C-PanCK-011 E1-I7V-C-PanCK
- GSM9040206 E1-I7V-C-IBA1-012 E1-I7V-C-IBA1
- GSM9040207 E1-I7V-C-PanCK-012 E1-I7V-C-PanCK
- GSM9040208 E1-I14V-C-IBA1-013 E1-I14V-C-IBA1
- GSM9040209 E1-I14V-C-PanCK-013 E1-I14V-C-PanCK
- GSM9040210 E1-I14V-M-IBA1-014 E1-I14V-M-IBA1
- GSM9040211 E1-I14V-M-PanCK-014 E1-I14V-M-PanCK
- GSM9040212 E1-I14V-M-IBA1-015 E1-I14V-M-IBA1
- GSM9040213 E1-I14V-M-PanCK-015 E1-I14V-M-PanCK
- GSM9040214 E1-I14V-C-IBA1-016 E1-I14V-C-IBA1
- GSM9040215 E1-I14V-C-PanCK-016 E1-I14V-C-PanCK
- GSM9040216 E1-I7E-C-IBA1-017 E1-I7E-C-IBA1
- GSM9040217 E1-I7E-C-PanCK-017 E1-I7E-C-PanCK
- GSM9040218 E1-I7E-C-IBA1-018 E1-I7E-C-IBA1
- GSM9040219 E1-I7E-C-PanCK-018 E1-I7E-C-PanCK
- GSM9040220 E1-I7E-M-IBA1-019
- GSM9040221 E1-I7E-M-PanCK-019
- GSM9040222 E1-I14E-M-IBA1-020 E1-I14E-M-IBA1
+ 54 more — browse all 94 samples with per-sample file links →
- GSE308709 Cellular and Spatial Drivers of Unresolved Injury Link to Functional Decline in the Human Kidney 36 samples shares spatial, kidney, injury
- GSE252772 Spatial characterization of sex differential regulations in kidney across lifespan 88 samples shares spatial, kidney
- GSE280514 Spatially-restricted and ontogenically-distinct hepatic macrophages are required for tissue repair. 48 samples shares spatial, repair
- GSE280652 Spatially-restricted and ontogenically-distinct hepatic macrophages are required for tissue repair. 42 samples shares spatial, repair
- GSE294678 Dietary restriction mitigates vascular aging, modulates the cGAS-STING pathway and reverses macrophage-like VSMC phenotypes in progeroid DNA-repair-deficient Ercc1Δ/- mice 29 samples shares modulates, repair
- GSE268876 Spatially clustered type I interferon responses at injury borderzones [scRNA-Seq] 12 samples shares spatial, injury
- GSE245316 Spatially restricted immune and microbiota-driven adaptation of the gut 72 samples shares spatial
- GSE300288 Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [scRNA-seq] 31 samples shares spatial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.