Transcriptional changes in response to TGFB in human pancreatic stellate cells with knockdown of PIN1
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 5 × hPSC, shSCR, untreated, vs 5 × hPSC, shSCR, TGFB, vs 5 × hPSC, shPIN1, untreated, vs 5 × hPSC, shPIN1, TGFB,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic CancerCancer research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299852_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1277147 and SRA study SRP592198. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9047771 hPSC, shSCR, untreated, rep1 hPSC, shSCR, untreated,
- GSM9047772 hPSC, shSCR, TGFB, rep1 hPSC, shSCR, TGFB,
- GSM9047773 hPSC, shPIN1, untreated, rep1 hPSC, shPIN1, untreated,
- GSM9047774 hPSC, shPIN1, TGFB, rep1 hPSC, shPIN1, TGFB,
- GSM9047775 hPSC, shSCR, untreated, rep2 hPSC, shSCR, untreated,
- GSM9047776 hPSC, shSCR, TGFB, rep2 hPSC, shSCR, TGFB,
- GSM9047777 hPSC, shPIN1, untreated, rep2 hPSC, shPIN1, untreated,
- GSM9047778 hPSC, shPIN1, TGFB, rep2 hPSC, shPIN1, TGFB,
- GSM9047779 hPSC, shSCR, untreated, rep3 hPSC, shSCR, untreated,
- GSM9047780 hPSC, shSCR, TGFB, rep3 hPSC, shSCR, TGFB,
- GSM9047781 hPSC, shPIN1, untreated, rep3 hPSC, shPIN1, untreated,
- GSM9047782 hPSC, shPIN1, TGFB, rep3 hPSC, shPIN1, TGFB,
- GSM9047783 hPSC, shSCR, untreated, rep4 hPSC, shSCR, untreated,
- GSM9047784 hPSC, shSCR, TGFB, rep4 hPSC, shSCR, TGFB,
- GSM9047785 hPSC, shPIN1, untreated, rep4 hPSC, shPIN1, untreated,
- GSM9047786 hPSC, shPIN1, TGFB, rep4 hPSC, shPIN1, TGFB,
- GSM9047787 hPSC, shSCR, untreated, rep5 hPSC, shSCR, untreated,
- GSM9047788 hPSC, shSCR, TGFB, rep5 hPSC, shSCR, TGFB,
- GSM9047789 hPSC, shPIN1, untreated, rep5 hPSC, shPIN1, untreated,
- GSM9047790 hPSC, shPIN1, TGFB, rep5 hPSC, shPIN1, TGFB,
- GSE299851 Transcriptional changes in response to TGFB in human pancreatic stellate cells with inhibition of PIN1 18 samples shares tgfb, pin1, pancreatic, stellate, changes
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- GSE319951 Effect of pancreatic tumor interstitial fluid media on transcriptional responses in PDAC cells 54 samples shares pancreatic
- GSE335339 PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension [BID-seq] 20 samples shares tgfb
- GSE143584 Gene expression from laser capture microdissected epithelium and stroma during pancreatic carcinogenesis 366 samples shares pancreatic
- GSE205154 Bulk RNA-Seq gene expression data for 289 primary and metastatic pancreatic ductal adenocarcinoma (PDAC) tumor samples from FFPE blocks. 289 samples shares pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.