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Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [CUT&Run]

GSE299960 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 70 samples Submitted 2025/10/08 Platform GPL18573
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 70 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Topic
Chronic lymphocytic leukemiaThis series is part of our curated briefing on it.
Samples
70 samples: 63 distinct titles, 7 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemiaBlood · 2025
Summary (written by the submitters)
The main goal of this study was to assess the role of LEF1 in patient-derived CLL cells.
Published in
Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia
Mateos-Jaimez J, Vidal-Crespo A, Charalampopoulou S et al. · Blood 2025 · PMID 40983031 · doi:10.1182/blood.2025030129
This dataset
Open GSE299960 in finder → Find more human ChIP / ATAC / CUT&Tag datasets → Chronic lymphocytic leukemia landscape →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299960_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1277730 and SRA study SRP592738. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40983031) ↗
Study design
63 distinct titles, 7 of them repeated
M-CLL4_LEF1 ×2 M-CLL5_LEF1 ×2 M-CLL3_IgG ×2 M-CLL3_LEF1 ×2 U-CLL12_IgG ×2 U-CLL12_LEF1 ×2 U-CLL1_LEF1 ×2

How we read this: Read from 70 sample titles: 63 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 30 more — browse all 70 samples with per-sample file links →

More Chronic lymphocytic leukemia datasets

Search all human ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.