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Transcriptomic analysis of KLRG1+CD127- CD8 T cells in the liver following treatment with anti-CD137 agonistic antibody

GSE300148 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/03 Platform GPL21493
Summary
We have employed bulk RNA sequencing approach to study cells associated with hepatotoxicity caused by treatment with anti-CD137 agonistic antibody. We found that the treatment-induced CD11c+KLRG1+ and CD11c-KLRG1+ CD8 T cells were main producers of IFNγ in the liver, suggesting their pathogenic role in the hepatotoxicity. Transcriptomic analysis revealed differential gene expression of inhibitory receptor NKG2A, activating receptor NKG2D, granzyme A, and adhesion molecule Ly6C in the CD11c+ population. This study represents the analysis of CD11c+ and CD11c- populations of KLRG1+CD127- CD8 T cells in the liver following anti-CD137 agonistic antibody treatment.
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Direct links to NCBI, no account and no request form: the whole study as GSE300148_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1279126 and SRA study SRP592933. Searching any of these in the dataset finder brings you back here.

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