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Expression data of neonatal brain from male intra-cytoplasmic sperm injection(ICSI)-F2 offspring

GSE300656 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/04/21 Platform GPL13112
Summary
Various behavioural abnormalities were observed in the F2 offspring of ICSI (Kanatsu-Shinohara et al., 2023, J. Clin. Invest. 133(22):e170140). The data presented here aim to clarify the cause of these abnormalities, and gene expression in the neonatal brain was investigated using RNA sequencing (RNAseq). ICSI was performed using C57BL/6 epididymal sperm and oocytes. Males from the F1 generation were naturally mated with C57BL/6 females to produce the F2 generation. Gene expression in the neonatal brains of male ICSI-F2 offspring was examined. Each group contains four biological replicates.
Published in
Mouse ICSI impairs fertility of male offspring by disruption of fetomaternal tolerance
Kanatsu-Shinohara M, Shiromoto Y, Ogonuki N et al. · Development (Cambridge, England) 2026 · PMID 42095840 · doi:10.1242/dev.205500
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Also filed as BioProject PRJNA1281614 and SRA study SRP594304. Searching any of these in the dataset finder brings you back here.

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