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Durable control of autoimmunity requires sustained stimulation of regulatory T cells

GSE300669 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/30 Platform GPL24247
Summary
Low-dose recombinant interleukin-2 (rIL-2) therapy holds significant promise for treating autoimmune and inflammatory disorders by selectively expanding the endogenous pool of CD4⁺Foxp3⁺ regulatory T cells (Tregs). However, clinical benefits are limited by the suboptimal pharmacokinetic profile of rIL-2, which fails to support sustained Treg activation. Here we investigated the efficacy of a long-lasting IL-2-based biologic mIL-2/CD25 to limit type 1 diabetes in female NOD mice when administered in a manner to cause periodic versus continual increases in Tregs. We find that the latter is highly effective in limiting autoimmunity and leads to substantial remodeling of the pancreatic islet immune landscape, which has important implications for advancing IL-2-based therapies for autoimmunity.
Published in
Durable control of autoimmunity requires sustained stimulation of regulatory T cells
Põder J, Yu A, Ding Y et al. · Cell reports 2026 · PMID 42012980 · doi:10.1016/j.celrep.2026.117292
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Also filed as BioProject PRJNA1281644 and SRA study SRP594341. Searching any of these in the dataset finder brings you back here.

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